Biomolecular and clinical epidemiology of diabetes, obesity and metabolic
syndrome
syndrome
Biomolecular and clinical epidemiology of diabetes, obesity and metabolic
General objective: To study the epidemiology of diabetes mellitus and related
Specific objectives: To study new prognostic biomarkers for glycaemia impairment (specifically, miRNAs) To study the sociodemographic, clinical and environmental factors associated with diabetes in adulthood.
To study the sociodemographic, clinical and environmental factors associated
with cardiovascular events in adulthood
El grupo
IP: Gemma Rojo Martínez
UGC Endocrinología y Nutrición. IBIMA. CIBERDEM
Pabellón 5 Sótano Hospital Civil (Hospital Regional Universitario de Málaga)
29009-Málaga
Contact
Title
Ongoing and finished grants in the last five years
Air polution and risk of diabetes onset in adult Spanish. Involvement of miRNAs.
INVESTIGADOR PRINCIPAL: Sergio Valdes Hernandez
INVESTIGADORES COLABORADORES: Gemma Rojo Martínez (coIP), Cristina Maldonado, Viyey K. Doulatram, Miguel Calderón, Ana Maria Lago Sampedro
DURACIÓN: 2018-2020 PRESUPUESTO: 111.320,00€
FINANCIADO POR: FIS (Instituto de Salud Carlos III)
Validation of a sera miRNAs profile predicting risk of developing type 2 diabetes in subjects from the DI@BET.ES study.
INVESTIGADOR PRINCIPAL: Sara García Serrano
INVESTIGADORES COLABORADORES: Gemma Rojo Martínez, Eduardo García Fuentes y Natalia Colomo.
DURACIÓN: 2017-2019 PRESUPUESTO: 50.000,00€
FINANCIADO POR: Servicio Andaluz de Salud
Study of circulating miRNAs involved in the regulation of VEGF-β and its modulation by food in the DI@BET.ES study. In vitro functional study and fatty-acid regulated mechanisms.
INVESTIGADOR PRINCIPAL: Eva García Escobar
INVESTIGADORES COLABORADORES: Sara García Serrano, Inmaculada González Molero, Natalia Colomo y Said Lhamiany
DURACIÓN: 2019-2021 PRESUPUESTO: 117.370,00€
FINANCIADO POR: Instituto de Salud Carlos III
Incidence of thyroid disfunction in Spain. Incidencia de disfunción tiroidea en España. DI@BET.ES study.
INVESTIGADOR PRINCIPAL: Natalia Colomo Rodríguez
INVESTIGADORES COLABORADORES: Sergio Valdés Hernández, Cristina Maldonado Araque, María José Tapia Guerrero, Pilar Ocón Sánchez e Inmaculada Rueda Fernández
DURACIÓN: 2019-2020 PRESUPUESTO: 48.863,79€
FINANCIADO POR: Consejería de Innovación Junta de Andalucía
Incidence of type 2 diabetes in the DI@BET.ES study. Role of fatty acids and VEGF-β-regulated carrying system in the development of metabolic diseases.
INVESTIGADOR PRINCIPAL: Gemma Rojo Martínez
INVESTIGADORES COLABORADORES: Sergio Valdés Hernández, Miguel Ángel Alaminos Castillo, Ana María Lago Sampedro, Roberto Monastero, Vidal Pérez Valero, María Ángeles Santos Matas
DURACIÓN: 2015-2017 PRESUPUESTO: 123.420,00€
FINANCIADO POR: FIS (Instituto de Salud Carlos III)
Understanding obesity (Ob), metabolic syndrome (MetS), type 2 diabetes (T"DM) and fatty liver disease (FL): a multidisciplinary approach
INVESTIGADOR PRINCIPAL: Gemma Rojo Martínez
INVESTIGADORES COLABORADORES: Jose María Mato de la Paz, Gabriel Olveira, Sergio Valdés Hernández, Sara García Serrano, Eva García Escobar, Francisco J Bermudez Silva, Natalia Colomo Rodríguez
DURACIÓN: 2015-2017 PRESUPUESTO: 660,000€
FINANCIADO POR: FIS (Instituto de Salud Carlos III)
Incidence of type 2 diabetes in Spain (the DI@BET.ES study)
INVESTIGADOR PRINCIPAL: Gemma Rojo Martínez
DURACIÓN: 2016-2017 PRESUPUESTO: 100.000,00€
FINANCIADO POR: Intramuros CIBERDEM
Role of fatty acid transport and its regulation by VEGF-β during diabetes onset.
INVESTIGADOR PRINCIPAL: Gemma Rojo Martínez
INVESTIGADORES COLABORADORES: Curra Linares Parrado, Francisca Rodríguez Pacheco, Stella González Romero, Juan Haro Mora, Juan Miguel Gómez Zumaquero
DURACIÓN: 2011-2013 PRESUPUESTO: 103.740,56€
FINANCIADO POR: Consejería de Innovación Junta de Andalucía
Type 2 diabetes prevention. The EGABRO-PIZARRA study.
INVESTIGADOR PRINCIPAL: Gemma Rojo Martínez
DURACIÓN: 2010-2012 PRESUPUESTO: 190,000€
FINANCIADO POR: Consejería de Innovación Junta de Andalucía
Towards the elimination of iodine deficiency and preventable thyroid-related diseases in Europe (EUthroid)
INVESTIGADOR PRINCIPAL: Prof. Henry Völzke emma Rojo Martínez
DURACIÓN: 2016-2019 PRESUPUESTO: 3,375,330€
FINANCIADO POR: European Commission
ENDAPASI, European Nutritional Phenotype Assessment and Data Sharing Initiative
INVESTIGADOR PRINCIPAL: Pamela Byrne
DURACIÓN: 2015-2018 PRESUPUESTO: 2,278,388.45€
FINANCIADO POR: European Joint Programming Initiative (JPI)
Collaborators
Luis Castaño
Hospital Universitario de Cruces, Barakaldo
Josep Franch
Institut Català de la Salut, Red GEDAPS, Barcelona
Alfonso Calle
Hospital Universitario San Carlos, Madrid
Elías Delgado
Hospital General de Asturias, Oviedo
Javier Chaves
Hospital Clínico Universitario de Valencia
Josep Ribalta
Universidad Rovira i Virgili, Tarragona
Relevant Publications
Valdés S, Doulatram-Gamgaram V, Lago A, García Torres F, Badía-Guilén R, Olveira G, Goday A, Calle-Pascual A, Castaño L, Castell C, Delgado E, Menendez E, Franch-Nadal J, Gaztambide S, Girbés J, Gomis R, Ortega E, Galán-García JL, Aguilera-Venegas G, Soriguer F, Rojo-Martínez G. Ambient temperature and prevalence of diabetes and insulin resistance in the Spanish population: Di@bet.es study. Eur J Endocrinol. 2019 May 1;180(5):273-280. doi: 10.1530/EJE-18-0818. PubMed PMID: 30840583
Lago-Sampedro A, García-Escobar E, Rubio-Martín E, Pascual-Aguirre N, Valdés S, Soriguer F, Goday A, Calle-Pascual A, Castell C, Menéndez E, Delgado E, Bordiú E, Castaño L, Franch-Nadal J, Girbés J, Chaves FJ, Gaztambide S, Rojo-Martínez G, Olveira G. Dairy Product Consumption and Metabolic Diseases in the Di@bet.es Study. Nutrients. 2019 Jan 24;11(2). pii: E262. doi: 10.3390/nu11020262. PubMed PMID: 30682848; PubMed Central PMCID: PMC6412325.
Maldonado-Araque C, Valdés S, Lago-Sampedro A, Lillo-Muñoz JA, Garcia-Fuentes E, Perez-Valero V, Gutierrez-Repiso C, Goday A, Urrutia I, Peláez L, Calle-Pascual A, Castaño L, Castell C, Delgado E, Menendez E, Franch-Nadal J, Gaztambide S, Girbés J, Ortega E, Vendrell J, Chacón MR, Chaves FJ, Soriguer F, Rojo-Martínez G. Iron deficiency is associated with Hypothyroxinemia and Hypotriiodothyroninemia in the Spanish general adult population: Di@bet.es study. Sci Rep. 2018 Apr 26;8(1):6571. doi: 10.1038/s41598-018-24352-9. PubMed PMID: 29700318; PubMed Central PMCID: PMC5919900.
Pinart M, Nimptsch K, Bouwman J, Dragsted LO, Yang C, De Cock N, Lachat C, Perozzi G, Canali R, Lombardo R, D’Archivio M, Guillaume M, Donneau AF, Jeran S, Linseisen J, Kleiser C, Nöthlings U, Barbaresko J, Boeing H, Stelmach-Mardas M, Heuer T, Laird E, Walton J, Gasparini P, Robino A, Castaño L, Rojo-Martínez G, Merino J, Masana L, Standl M, Schulz H, Biagi E, Nurk E, Matthys C, Gobbetti M, de Angelis M, Windler E, Zyriax BC, Tafforeau J, Pischon T. Joint Data Analysis in Nutritional Epidemiology: Identification of Observational Studies and Minimal Requirements. J Nutr. 2018 Feb 1;148(2):285-297. doi: 10.1093/jn/nxx037. PubMed PMID: 29490094.
Lozano-Bartolomé J, Llauradó G, Portero-Otin M, Altuna-Coy A, Rojo-Martínez G, Vendrell J, Jorba R, Rodríguez-Gallego E, Chacón MR. Altered Expression of miR-181a-5p and miR-23a-3p Is Associated With Obesity and TNFα-Induced Insulin Resistance. J Clin Endocrinol Metab. 2018 Apr 1;103(4):1447-1458. doi: 10.1210/jc.2017-01909. PubMed PMID: 29409019.
Valdés S, Maldonado-Araque C, Lago-Sampedro A, Lillo-Muñoz JA, Garcia-Fuentes E, Perez-Valero V, Gutiérrez-Repiso C, Garcia-Escobar E, Goday A, Urrutia I, Peláez L, Calle-Pascual A, Bordiú E, Castaño L, Castell C, Delgado E, Menéndez E, Franch-Nadal J, Gaztambide S, Girbés J, Ortega E, Vendrell J, Chacón MR, Javier Chaves F, Soriguer F, Rojo-Martínez G. Reference values for TSH may be inadequate to define hypothyroidism in persons with morbid obesity: Di@bet.es study. Obesity (Silver Spring). 2017 Apr;25(4):788-793. doi: 10.1002/oby.21796. Epub 2017 Mar 9. PubMed PMID: 28276648.
Valdés S, Maldonado-Araque C, Lago-Sampedro A, Lillo JA, Garcia-Fuentes E, Perez-Valero V, Gutiérrez-Repiso C, Ocon-Sanchez P, Goday A, Urrutia I, Peláez L, Calle-Pascual A, Bordiú E, Castaño L, Castell C, Delgado E, Menéndez E, Franch-Nadal J, Gaztambide S, Girbés J, Ortega E, López-Alba A, Chaves FJ, Vendrell J, Chacón MR, , Soriguer F, Rojo-Martínez G. Population-Based National Prevalence of Thyroid Dysfunction in Spain and Associated Factors: Di@bet-es. Study. Thyroid. 2017 Feb;27(2):156-166. doi: 10.1089/thy.2016.0353. Epub 2017 Jan 4. PubMed PMID: 27835928.
Walford GA, Gustafsson S, Rybin D, Stančáková A, Chen H, Liu CT, Hong J, Jensen RA, Rice K, Morris AP, Mägi R, Tönjes A, Prokopenko I, Kleber ME, Delgado G, Silbernagel G, Jackson AU, Appel EV, Grarup N, Lewis JP, Montasser ME, Landenvall C, Staiger H, Luan J, Frayling TM, Weedon MN, Xie W, Morcillo S, Martínez-Larrad MT, Biggs ML, Chen YD, Corbaton-Anchuelo A, Færch K, Gómez-Zumaquero JM, Goodarzi MO, Kizer JR, Koistinen HA, Leong A, Lind L, Lindgren C, Machicao F, Manning AK, Martín-Núñez GM, Rojo-Martínez G, Rotter JI, Siscovick DS, Zmuda JM, Zhang Z, Serrano-Rios M, Smith U, Soriguer F, Hansen T, Jørgensen TJ, Linnenberg A, Pedersen O, Walker M, Langenberg C, Scott RA, Wareham NJ, Fritsche A, Häring HU, Stefan N, Groop L, O’Connell JR, Boehnke M, Bergman RN, Collins FS, Mohlke KL, Tuomilehto J, März W, Kovacs P, Stumvoll M, Psaty BM, Kuusisto J, Laakso M, Meigs JB, Dupuis J, Ingelsson E, Florez JC. Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci. Diabetes. 2016 Oct;65(10):3200-11. doi: 10.2337/db16-0199. Epub 2016 Jul 14. PubMed PMID: 27416945; PubMed Central PMCID: PMC5033262.
Martín-Núñez GM, Rubio-Martín E, Cabrera-Mulero R, Rojo-Martínez G, Olveira G, Valdés S, Soriguer F, Castaño L, Morcillo S. Type 2 diabetes mellitus in relation to global LINE-1 DNA methylation in peripheral blood: a cohort study. Epigenetics. 2014 Oct;9(10):1322-8. doi: 10.4161/15592294.2014.969617. PubMed PMID: 25437047; PubMed Central PMCID: PMC4622014.
Valdés S, García-Torres F, Maldonado-Araque C, Goday A, Calle-Pascual A, Soriguer F, Castaño L, Catalá M, Gomis R, Rojo-Martínez G; Di@bet.es study group. Prevalence of obesity, diabetes and other cardiovascular risk factors in Andalusia (southern Spain). Comparison with national prevalence data. The Di@bet.es study. Rev Esp Cardiol (Engl Ed). 2014 Jun;67(6):442-8. doi: 10.1016/j.rec.2013.09.029. Epub 2014 Feb 26. PubMed PMID: 24863592.
Soriguer F, Goday A, Bosch-Comas A, Bordiú E, Calle-Pascual A, Carmena R, Casamitjana R, Castaño L, Castell C, Catalá M, Delgado E, Franch J, Gaztambide S, Girbés J, Gomis R, Gutiérrez G, López-Alba A, Martínez-Larrad MT, Menéndez E, Mora-Peces I, Ortega E, Pascual-Manich G, Rojo-Martínez G, Serrano-Rios M, Valdés S, Vázquez JA, Vendrell J. Prevalence of diabetes mellitus and impaired glucose regulation in Spain: the Di@bet.es Study. Diabetologia. 2012 Jan;55(1):88-93. doi: 10.1007/s00125-011-2336-9. Epub 2011 Oct 11. PubMed PMID: 21987347; PubMed Central PMCID: PMC3228950.
Available Techniques
- Design and implementation of epidemiological surveys
- Design of field studies
- Measurement of food intake (frequency surveys, prospective surveys, food intake patterns)
- Physical activity and other habits assessment
- Prospective collections of Biobank-stored biological samples (serum, plasma, whole blood)
- Genotyping
- Epigenetic (methylation patterns and miRNAs determination)
- Assessment of biomarkers in blood and urine samples
- Databases implementation
- Statistical analysis of data, automated learning
- Bioinformatic analysis
- SNP Genotyping
- Immunoassays
