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Clinical Epidemiology
  • Design and implementation of epidemiological surveys
  • Design of field studies
  • Measurement of food intake (frequency surveys, prospective surveys, food intake patterns)
  • Physical activity and other habits assessment
  • Prospective collections of Biobank-stored biological samples (serum, plasma, whole blood)
  • Genotyping
  • Epigenetic (methylation patterns and miRNAs determination)
  • Assessment of biomarkers in blood and urine samples
  • Databases implementation
  • Statistical analysis of data, automated learning
  • Bioinformatic analysis
  • SNP Genotyping
  • Immunoassays
Clinical Research
  • Surveys for screening of psychological alterations associated with diabetes
  • Psychometric analysis
  • Cost-effectiveness analysis of ICTs applied to diabetes
  • ICTs applied to health: Application of a new online tool for the treatment of
    depression in patients with type 1 diabetes
  • Clinical studies in people with T1D
  • Telemedicine in T1D
  • Implementation and monitorization of new diabetes technologies
  • Analysis of amino acids and acylcarnitines in dried blood by MS / MS
  • Simultaneous determination in dried blood of methylmalonic acid, methyl citric
    acid and total homocysteine ​​by LC-MS / MS.
  • Determination of immunoreactive trypsinogen and thyrotropin in dried blood by
    immunofluorimetric method (DELFIA).
  • Determination of hemoglobin variants in dried blood by HPLC
  • Cuantification of chloride in sweat (diagnosis of cystic fibrosis).
  • Body composition techniques (Bioelectrical Impedance, Applied anthropometry)
  • Hand grip dynamometry and legs
  • Indirect calorimetry
  • Dual-Energy X-ray Absorptiometry
  • Muscle ultrasound
  • Software for assessment of muscle composition at the level of L3 on CT
  • Assessment of dietary intake (Frequency and prospective surveys, Food intake patterns, Own software for intake assessment: Dietstat®)
  • Screening tools and structured nutritional assessment (Subjective global assessment, MNA®, MUST, NRS 2002, SNAQ)
  • Exercise valuation (6 minute walk test SPPB, Physical activity questionnaires (IPAQ), Cardiopulmonary exercise test, Accelerometers (wGT3X ActiGraph®))
  • Dysphagia screening and assessment tools (Volume-viscosity test (MECV-V),
    EAT 10 ®, Water test)
  • Quality of life assessment (SF 12, QOLB Spain, CFQR Spain, St George)
  • Assessment of psychological symptoms (anxiety and depression, HADS)
  • Participation in national and international registries for bronchiectasis,inpatients and outpatients artificial nutrition (NADYA), cystic fibrosis, outpatients parenteral nutrition
  • Prospective collections of samples (serum, plasma, whole blood, feces) from cystic fibrosis, bronchiectasis, parenteral nutrition and diabetes, obesity, type 1 diabetes, type 2 diabetes, chronic kidney disease)
  • Observational Clinical Trials
  • Interventional Clinical Trials, Phases I-IV
  • Nutritional Intervention Clinical trials
Basic and translational research:
  • Quantification of gene expression in PBMCs or tissue by RT qPCR
  • Protein expression by Immunohistochemistry, immunocytochemistry, immunofluorescence, electron microscopy and Western Blot
  • Analysis of DNA-protein interaction by EMSA assay
  • Analysis of epigenetic changes (miRNAs and DNA methylation)
  • Bioinformatic analysis of miRNAs (function, target genes) by Mirtabase,DAVID, PANTHER, Cytoscape software
  • Quantification of hormones and cytokines by ELISA and multiplex assays in plasma/serum and cell/tissue extracts
  • Isolation, phenotyping, culture and differentiation of mesenchimal stem cells derived from adipose tissue to white, beige and brown adipocytes, osteocytes and endothelial cells
  • Tissue culture of adipose and brain, cell lines and primary culture of human, mouse and rat adipocytes, peripheral cells and macrophages
  • Human and murine islets of Langerhans handling, including fresh murine islet isolation and ex vivo study of insulin and glucagon secretion, viability, apoptosis and proliferation
  • In vitro experiments in beta cell lines (MIN-6)
  • Mouse models for the study of the cannabinoid type 1 receptor (CB1R): Global CB1R knockout mice and inducible beta cell-specific CB1R knockout mice (MIP-Cre CNR1 LoxP/LoxP )
  • Type 1 diabetes mouse models: Non-Obese Diabetic (NOD) and streptozotocin (STZ)-injected mice
  • Mouse models of high-fat-diet-induced obesity, prediabetes and type 2 diabetes
  • Metabolic assessment of the effects of drugs and food supplements in animal models of obesity, pre-diabetes and type 2 diabetes
  • Analysis of inflammatory and oxidative processes in animal models