Skip to main content

Clinical Research

Clinical Nutrition

Clinical Nutrition and Dietetics is a transversal discipline that intervenes in
almost all the diseases that are treated at both the hospital and outpatient level.
This research line supports and complements the other research lines of the
group, such as obesity, type 1 diabetes, type 2 diabetes, epidemiology of
diabetes, etc. although it is specifically focuses on disease-related malnutrition (DRM). In recent years we have developed numerous research projects applied to different pathologies (usually chronic) relating nutritional status with various aspects of diseases highlighting: tools for screening and diagnosis of nutritional status, treatment with artificial nutrition (enteral, parenteral) or diet and exercise, pathophysiological bases of DRM (inflammation, oxidation …), relationship of nutrition with prognosis (morbidity and mortality) and quality of life. We also actively collaborate with other national and international groups and specialties of our center (IBIMA).
We investigated in malnutrition associated to diseases such as:
• Nutrition in chronic respiratory diseases (cystic fibrosis and bronchiectasis)
• Nutritional intervention in chronic kidney disease
• Artificial nutrition (enteral and parenteral) in hyperglycemia and diabetes
• Home parenteral nutrition
• Nutritional assessment and nutritional intervention in cancer patients
• Nutritional assessment and treatment in patients with oropharyngeal
dysphagia
• Nutritional assessment and treatment in patients with hip fracture.
• Nutrition in morbid obesity surgical
• Nutrition in eating behavior disorders
• Nutritional assessment and treatment in metabolic diseases (of the adult)
• Benefits of goat dairy in human health

PRINCIPAL INVESTIGATOR

Gabriel Olveira Fuster
UGC Endocrinología y Nutrición. IBIMA.

Servicio de Endocrinología y Nutrición
Hospital Civil . Plaza del Hospital Civil s/n Málaga, 29009

Contact

Ongoing and finished grants in the last five years

Effect of an oral supplement on the nutritional and functional status and levels of expression of circulating microRNAs as well as their target genes, in malnourished people on hemodialysis.

INVESTIGADOR PRINCIPAL: Gabriel Olveira Fuster

DURACIÓN: 2019-2021 PRESUPUESTO: 93.170,00€

FINANCIADO POR: FIS (Instituto de Salud Carlos III)

Nutritional supplements with pro-biotics for the dietetic treatment of chronic diseases (sunespro17)” Ministerio de Ciencia, Innovación y Universidades.

INVESTIGADOR PRINCIPAL: Gabriel Olveira Fuster

DURACIÓN: 2017 PRESUPUESTO: 119.228,04 €

FINANCIADO POR: Ministerio de Ciencia, Innovación y Universidades

High-resolution plasma metabolomics for nutrition-related metabolic assessment in adults with cystic fibrosis.

INVESTIGADOR PRINCIPAL: Jessica Alejandra Alvarez

IP EN ESPAÑA: Gabriel Olveira Fuster.

DURACIÓN: 2018-2020 PRESUPUESTO: 104.966,09 €

FINANCIADO POR: National Institutes of Health de Estados Unidos

Subcutaneous versus intravenous basal insulin in non-critic diabetic inpatients with total parenteral nutrition.

INVESTIGADOR PRINCIPAL: Gabriel Oliveira Fuster

DURACIÓN: 2016-2019 PRESUPUESTO: 98.615,00 €

FINANCIADO POR: FIS (Instituto de Salud Carlos III)

Pulmonar rehabilitation versus pulmonar rehabilitation plus specific nutritional supplement in patients with bronchiectasis. Randomized Clinical Trial.

INVESTIGADOR PRINCIPAL: Gabriel Oliveira Fuster

DURACIÓN: 2013-2016 PRESUPUESTO: 48.933,47€

FINANCIADO POR: Consejería de Salud

CAPRITEC- New technologies por optimizing nutritional properties and production of goat milk and related products in Andalusia.

INVESTIGADOR PRINCIPAL: Gabriel Oliveira Fuster

DURACIÓN: 2013-2014 PRESUPUESTO: 119.000,00€

FINANCIADO POR: CDTI FEDER INTERCONNECTA

Efficacy of intragastric endoscopic injection of botulinum toxin in obese patients waiting for bariatric surgery.

INVESTIGADOR PRINCIPAL: Gabriel Oliveira Fuster

CoIP: María José Tapia Guerrero

DURACIÓN: 2016-2019 PRESUPUESTO: 12.000,00€

FINANCIADO POR: FIMABIS

Understanding obesity (Ob), metabolic syndrome (MetS), type 2 diabetes (T2DM) and fatty liver disease (FL): a multidisciplinary approach .

COLABORADOR: Gabriel Oliveira Fuster

DURACIÓN: 2015-2018 PRESUPUESTO: 660.000,00€

FINANCIADO POR: Proyecto INTERCIBER

Nutritional assessment of inpatients diagnosed with solid and haematological neoplasm by body composition techniques.

INVESTIGADOR PRINCIPAL: Gabriel Oliveira Fuster

Co IP: Victoria Contreras Bolívar.

DURACIÓN: 2017-2020 PRESUPUESTO FIMABIS: 16.000,00€

PRESUPUESTO SAEDYN: 6.000,00€

FINANCIADO POR: FIMABIS y SAEDYN (Sociedad Andaluza de Endocrinologia y Nutrición).

Implementation of neurological disphagia screening and treatment in inpatients with ictus.

INVESTIGADOR PRINCIPAL: Gabriel Oliveira Fuster

Co IP: Rosario Vallejo Mora

DURACIÓN: 2018-2019 PRESUPUESTO: 12.000,00€

FINANCIADO POR: FIMABIS

Implementation of a protocol for screening, assessment and nutritional intervention in elderly inpatients with hip fracture.

INVESTIGADOR PRINCIPAL: Gabriel Oliveira Fuster

Co IP:  Victoria Contreras Bolívar

DURACIÓN: 2019-2020 PRESUPUESTO: 16.000,00€

FINANCIADO POR: FIMABIS

Presurgical assessment of the nutritional status in patients with colon and rectum neoplasm. Implementation of a protocol for screening and nutritional intervention (Prequinut study)

INVESTIGADOR PRINCIPAL: Gabriel Oliveira Fuster

Co IP:  Francisco José Sánchez Torralvo 

DURACIÓN: 2019-2020 PRESUPUESTO: 16.000,00€

FINANCIADO POR: FIMABIS

Global assessment of cardiovascular and renal risk and quality of life in patients with chronic obstructive pulmonary disease. Phenotypic differences and effect of respiratory rehabilitation.

INVESTIGADOR PRINCIPAL: Casilda Oliveira Fuster

DURACIÓN: 2014-2015 PRESUPUESTO: 6.000,00€

FINANCIADO POR: NEUMOSUR (Asociación de Neumología y Cirugía Torácica del Sur).

Pulmonar rehabilitation versus pulmonar rehabilitation plus specific nutritional supplement in patients with bronchiectasis. Randomized Clinical Trial.

INVESTIGADOR PRINCIPAL: Casilda Oliveira Fuster

CoIP: Gabriel Oliveira

DURACIÓN: 2014-2015 PRESUPUESTO: 6.000,00€

FINANCIADO POR: NEUMOSUR (Asociación de Neumología y Cirugía Torácica del Sur).

Collaborators

  • Jessica Alvarez

    Emory University

  • Francisco Tinahones Madueño

    Servicio de Endocrinología y Nutrición . Hospital Virgen de la Victoria. IBIMA.

  • José Manuel García Almeida

    Servicio de Endocrinología y Nutrición . Hospital Virgen de la Victoria. IBIMA

  • Área de nutrición de la SEEN

    Grupo para el estudio de la diabetes en Nutrición parenteral

  • SENPE

    Grupo de Nutrición artificial domiciliaria y ambulatoria

  • Área de nutrición de la SEEN

    Grupo de errores innatos del metabolismo

  • Sociedad Española de Neumología y Cirugía Torácica

    Programas integrados de investigación (PII de bronquiectasias)

  • Guillermina Barril

    Servicio de Nefrología. Hospital Universitario de la Princesa Madrid.

  • Home Artificial Nutrition & Chronic Intestinal Failure special interest group of ESPEN

    Loris Pironi . University of Bologna: Bologna, Emilia-Romagna

Relevant publications

Contreras-Bolívar, V Olveira, G Porras, N Acosta, E Rubio-Martín, E Tapia-Guerrero, M J, Abuin-Fernández, J Olveira, C.  Osteopenia and Osteoporosis in Patients with Bronchiectasis: Association with Respiratory Parameters, Body Composition, Muscle Strength and Bone Remodeling Biomarkers. Sci Rep. 2019 Oct 10;9(1):14496. doi: 10.1038/s41598-019-51069-0.Factor de impacto 2018= 4,001. Q1 (15/69). En la materia= MULTIDISCIPLINARY SCIENCES
Olveira G, Abuín J, López R, Herranz S, García-Almeida JM, García-Malpartida K, Ferrer M, Cancer E, Luengo-Pérez LM, Álvarez J, Aragón C, Ocón MJ, García-Manzanares Á, Bretón I, Serrano-Aguayo P, Pérez-Ferre N, López-Gómez JJ, Olivares J, Arraiza C, Tejera C, Martín JD, García S, Abad ÁL, Alhambra MR, Zugasti A, Parra J, Torrejón S, Tapia MJ. Regular Insulin added to Total Parenteral Nutrition vs Subcutaneous Glargine in Non-Critically ill diabetic inpatients, a multicenter randomized clinical trial: INSUPAR Trial. Clin Nutr. 2019 Mar 20. pii: S0261-5614(19)30090-1. doi: 10.1016/j.clnu.2019.02.036. [Epub ahead of print] PMID: 30930133 Factor de impacto 2017= 5,496. Q1-P (8/83). Decil= 1. En la materia= NUTRITION & DIETETICS.
Pironi L, Steiger E, Brandt C, Joly F, Wanten G, Chambrier C, Aimasso U, Sasdelli AS, Zeraschi S, Kelly D, Szczepanek K, Jukes A, Di Caro S, Theilla M, Kunecki M, Daniels J, Serlie M, Poullenot F, Wu J, Cooper SC, Rasmussen HH, Compher C, Seguy D, Crivelli A, Pagano MC, Hughes SJ, Guglielmi FW, Kozjek NR, Schneider SM, Gillanders L, Ellegard L, Thibault R, Matras P, Zmarzly A, Matysiak K, Van Gossum A, Forbes A, Wyer N, Taus M, Virgili NM, O’Callaghan M, Chapman B, Osland E, Cuerda C, Sahin P, Jones L, Won Lee AD, Masconale L, Orlandoni P, Izbéki F, Spaggiari C, Bueno M, Doitchinova-Simeonova M, Garde C, Serralde-Zúñiga AE, Olveira G, Krznaric Z, Czako L, Kekstas G, Sanz-Paris A, Jáuregui EP, Murillo AZ, Schafer E, Arends J, Suárez-Llanos JP, Lal S; Home Artificial Nutrition and Chronic Intestinal Failure Special Interest Group of ESPEN; European Society for Clinical Nutrition and Metabolism. Home parenteral nutrition provision modalities for chronic intestinal failure in adult patients: An international survey. Clin Nutr. 2019 Mar 25. pii: S0261-5614(19)30123-2. doi: 10.1016/j.clnu.2019.03.010. [Epub ahead of print] PMID: 30992207Factor de impacto 2017= 5,496. Q1-P (8/83). Decil= 1. En la materia= NUTRITION & DIETETICS.
Doña E, Olveira C, Palenque FJ, Porras N, Dorado A, Martín-Valero R, Godoy AM, Espíldora F, Contreras V, Olveira G. Body composition measurement in adults with bronchiecstasis: comparison between bioelectrical impedance analysis, skinfold thickness measurement and dual-energy x-ray absorptiometry before and after pulmonary rehabilitation. Journal of the Academy of Nutrition and Dietetics. J Acad Nutr Diet. 2018 Aug;118(8):1464-1473.Factor de impacto 2017= 4,021. Q1-U (20/83). En la materia= NUTRITION & DIETETICS
Rubio-Martín E, García-Escobar E, Ruiz de Adana MS, Lima-Rubio F, Peláez L, Caracuel AM, Bermúdez-Silva FJ, Soriguer F, Rojo-Martínez G, Olveira G Comparison of the Effects of Goat Dairy and Cow Dairy Based Breakfasts on Satiety, Appetite Hormones, and Metabolic Profile. .  2017 Aug 15;9(8). pii: E877. doi: 10.3390/nu9080877.   Factor de impacto 2017= En prensa Factor de impacto 2017= 4.196. Q1-U (18/83).  Nutrition and dietetics
Solé A, Olveira C, Pérez I, Hervás D, Valentine V, Baca Yepez AN, Olveira G, Quittner AL. Development and electronic validation of the revised Cystic Fibrosis Questionnaire (CFQ-R Teen/Adult): New tool for monitoring psychosocial health in CF.    J Cyst Fibros. 2018 Sep;17(5):672-679. doi: 10.1016/j.jcf.2017.10.015.  Respiratory system . 11 de 59 (Q1)
Alejandro Sanz-Paris, Julia Álvarez-Hernández, María D. Ballesteros-Pomar, Francisco Botella-Romero, Miguel León-Sanz, Ángela Martín-Palmero, Miguel Ángel Martínez-Olmos, Gabriel Olveira.  Evidence-based recommendations and expert consensus on enteral nutrition in the adult patient with diabetes mellitus or hyperglycemia. 2017 Sep;41:58-67. (Q2)
Gabriel Olveira, Casilda Olveira, Esperanza Doña, Francisco Javier Palenque,  Nuria Porras Pérez, Antonio Dorado,  Ana M. Godoy, Elehazara Rubio-Martínez, Gemma Rojo-Martínez, Rocío Martín-Valero. Oral supplement enriched in HMB combined with pulmonaryrehabilitation improves body composition and health related quality of life in patients with bronchiectasis (Prospective, Randomised Study)  Clin Nutr. 2016 Oct;35(5):1015-22. doi: 10.1016/j.clnu.2015.10.001.Factor de impacto 2014= 4,476. Q1-P (9/77). Decil= 2En la materia= NUTRITION & DIETETICS.
María José Tapia , Julia Ocón , Carmen Cabrejas-Gómez, María D. Ballesteros-Pomar , Alfonso Vidal-Casariego, Carmen Arraiza-Irigoyen , Josefina Olivares , Mª Carmen Conde-García , Álvaro García-Manzanares , Francisco Botella-Romero , Rosa P. Quílez-Toboso , Lucio Cabrerizo , Miguel A. Rubio , Luisa Chicharro , Rosa Burgos , Pedro Pujante , Mercedes Ferrer , Ana Zugasti , Estrella Petrina , Laura Manjón , Marta Diéguez , Mª José Carrera , Anna Vila-Bundo , Juan Ramón Urgelés , Carmen Aragón-Valera , Olga Sánchez-Vilar, Irene Bretón , Pilar García-Peris , Araceli Muñoz-Garach , Efren Márquez , Dolores del Olmo , José Luis Pereira, María C. Tous , Gabriel Olveira .Nutrition-related risk indexes and long-term mortality in noncritically ill inpatients who receive total parenteral nutrition (prospective multicenter study).    Clin Nutr. 2015 Oct;34(5):962-7. doi: 10.1016/j.clnu.2014.10.008. Epub 2014 Nov 13 Factor de impacto 2014= 4,476. Q1-U (9/77). Decil= 2En la materia= NUTRITION & DIETETICS
Olveira G; Tapia MJ; Ocón J; Cabrejas-Gómez C; Ballesteros-Pomar MD; Vidal-Casariego A; Arraiza-Irigoyen C; Olivares J; Conde-García MD; García-Manzanares A; Botella-Romero F; Quílez-Toboso RP; Cabrerizo L; Matia P; Chicharro L; Burgos R; Pujante P; Ferrer M; Zugasti A; Prieto J; Diéguez M; Carrera MJ; Vila-Bundo A; Urgelés JR; Aragón-Valera C; Rovira A; Bretón I; García-Peris P; Muñoz-Garach A; Márquez E; Del Olmo D; Pereira JL; Tous MC. Parenteral Nutrition-Associated Hyperglycemia in Noncritically Ill Inpatients Increases the Risk of In-hospital Mortality (Multicenter Study): Study Group of Hyperglycemia in Parenteral Nutrition: Nutrition Area of the Spanish Society of Endocrinology and Nutrition (SEEN) Diabetes Care. 2013 May;36(5):1061-6. Factor de impacto 2014= 8.420. Q1-P (8/122). Decil= 1 Categoría Endocrinology and metabolism PMID:23223407

Body composition techniques

– Bioelectrical Impedance Analysis ( TANITA MC980MA and AKERN
NUTRILAB).
– Applied anthropometry (tape measures, Skinfold
– Thickness Measurement (Holtain), Tallimeter (Holtain), clinical scales).
– Hand grip dynamometry (JAMAR) and legs.
– Indirect calorimetry (VMAX 29N SPECTRA EQUIPMENT)
– Dual-Energy X-ray Absorptiometry (Lunar Prodigy Advance densitometer)
– Muscle ultrasound (ESAOTE, Mylab six)
– Software for assessment of muscle composition at the level of L3 on CT
(Osirix®, Image J ®)

Assessment of dietary intake:

– Frequency and prospective surveys
– Food intake patterns
– Own software for intake assessment: Dietstat®

Screening tools and structured nutritional assessment:

– Subjective global assessment
– MNA®
– MUST
– NRS 2002
– SNAQ

Exercise valuation:

– 6 minute walk test
– SPPB (Short Physical Performance Battery)
– Physical activity questionnaires (IPAQ)
– Cardiopulmonary exercise test (in collaboration with the Pulmonology service)
– Accelerometers (wGT3X ActiGraph®).

Dysphagia screening and assessment tools:

– Volume-viscosity test (MECV-V)
– EAT 10 ®
– Water test

Prospective collections of samples (serum, plasma, whole blood, feces)

– Cystic fibrosis
– Bronchiectasis
– Parenteral nutrition and diabetes
– Obesity
– Type 1 diabetes
– Type 2 diabetes
– Chronic Kidney Disease